13. March 2018
For their nutritional and medicinal advantages, several bioactive compounds and ingredients are being used in the production of medical foods, functional foods and dietary supplements. As health consciousness among consumers increases, the demand for dietary supplements will witness an upsurge. In order to attain a stabilized manufacturing of these products, a range of nutraceutical excipients will be utilized.
04. January 2018
Calcium phosphates have been used in the pharmaceutical technology for many years. They have many physical and chemical properties that make them ideal candidates for the production of solid oral dosage forms. They are mainly used as fillers in order to bulk up formulations however, the function of calcium phosphates goes far beyond mere filler and the adequate utilisation of their full functionality can support achieving the intended formulation goals.
27. July 2016
Abstract The aim of the presented research was the preparation and in vitro and in vivo evaluation of mucoadhesive oral films containing nystatin. Multivariate data analysis was used to evaluate an innovative approach, in which a combination of different mucoadhesive polymers was employed. The purpose of this was to assess the effects of such a combination on non-woven insoluble carmellose textile as a drug-release modifier in the structure of the film. It was observed that the mucoadhesive...
14. June 2016
Abstract Lansoprazole degrades rapidly in an aqueous solution at low pH values. Degradation rate increases at pH values below 4 .The aim of this study was development of enteric coated pellets containing Lansoprazole by an extrusion/ spheronization technique. Eight different formulations based on lactose and six different formulations based on mannitol, consisting of different portions of other excipients including sucrose, hydroxy propyl methyl cellulose, magnesium carbonate, and sodium lauryl...
07. June 2015
The purpose of this study was to investigate the effect of pelletization aids, i.e., microcrystalline cellulose (MCC) and cross-linked polyvinyl pyrrolidone (XPVP), and filler, i.e., lactose, particle size on the surface roughness of pellets. Pellets were prepared from powder blends containing pelletization aid/ lactose in 1:3 ratio by extrusion–spheronization. Surface roughness of pellets was assessed quantitatively and qualitatively using optical interferometry and scanning electron...