02. May 2017
The multiparticulate drug product concept covering micropellets, pellets and mini-tablets is presented as a highly feasible approach to present convenient and patient friendly medication for the geriatric population. Improved swallowability and optimized administration regimen going along with defined drug dosage are
achievable. Extemporaneous preparation of medicines from standard medication can
be avoided going along with improved patient safety.
02. May 2017
A Wurster coating fluid bed process to directly produce enteric coated API particles was developed at lab and pilot scale - Generating API with a 3-dimensional structure was critical and was achieved through a wet milling process.
The starting particle size had D50 ~ 90 μm, and the D50 of the resulting coated particles could be as small as 180 μm. -Coated API particles achieved up to 8 h enteric protection in the gastric environment and rapid release in the intestinal environment.
30. September 2016
Abstract The moisture content of granules in fluidised bed drying, granulation and coating processes can typically be between 1%~25%, resulting in the change of permittivity and conductivity during the processes. Electrical capacitance tomography (ECT) has been used for this purpose, but has a limit because too much water can cause a problem in capacitance measurement. Considering that microwave tomography (MWT) has a wide range of frequency (1~2.5 GHz) and can be used to measure materials with...
19. May 2016
Investigational drugs are increasingly becoming less soluble in aqueous media thus presenting real challenges during development. Previous work has successfully demonstrated the manufacturing of pharmaceuticals using fluidized-bed (FB) impregnation of APIs onto porous carriers. This study demonstrates the usefulness of FB impregnation in formulating poorly-soluble drugs. We show that dissolution of Fenofibrate is greatly improved by FB impregnation onto Neusilin®, a synthetic amorphous form of...
25. April 2016
This study consists of two experimental designs. Within the first one, suitable technique for application of model drug onto inactive pellets was evaluated and formulation and process parameters with greatest impact to process efficency and useful yield were determined. Results of experiments showed that formulation characteristics were the ones with the greatest impact on coating efficiency and that suspension layering technique was signifficantly better for drug application onto inactive...
07. December 2015
Multiparticulate dosage forms are a recent strategy to meet the special needs of children, elderly people and patients suffering from dysphagia. Our study presents a novel and cost-efficient approach for the manufacturing of a taste-masked multiparticulate system with a stable immediate release profile by applying lipid-based excipients in a solvent-free hot melt coating process. More
30. November 2015
Multiparticulate dosage forms are a recent strategy to meet the special needs of children, elderly people and patients suffering from dysphagia. Our study presents a novel and cost-efficient approach for the manufacturing of a taste-masked multiparticulate system with a stable immediate release profile by applying lipid-based excipients in a solvent-free hot melt coating process. More
20. November 2015
Taste-masking techniques are applied to mask or overcome the bitter or unpleasant taste of active pharmaceutical ingredients/drugs to achieve patient acceptability and compliance. Oral administration of bitter or unpleasant tasting drugs is often the biggest barrier for patient groups, such as pediatrics and geriatrics. More See also