28. March 2018
Mini-tablets with diameters of 2.0, 2.5, and 3.0 mm are coated in two different lab-scale fluidized bed coaters equipped with a Wurster draft tube. The main focus of the research is to evaluate the inter-particle coating variability, and to assess the contribution of cycle time variation. Cycle times are measured using a photoluminescent tracer with a detector mounted on the top of the draft tube. The number of passes variability is represented from 5 to 28% of the total coating variability....
19. February 2018
The objective of this study was to assess the efficacy and the capability of a novel ethylcellulose-based dry-coating system to obtain prolonged and stable release profiles of caffeine-loaded pellets. Lauric and oleic acids at a suitable proportion were used to plasticize ethylcellulose. The effect of coating level, percentage of drug loading, inert core particle size, and composition of the coating formulation including the anti-sticking agent on the drug release profile were fully...
29. December 2016
Abstract A process to coat particles of active pharmaceutical ingredient (API) onto microcrystalline cellulose (MCC) excipient shows promise as a new way to dosage forms showing enhanced drug release. The process consists of a fluidized bed operated at elevated pressure in which API particles are precipitated from a Supercritical Anti-Solvent process (SAS). MCC particles were used as an excipient in the fluidized bed and collect the SAS-generated API particles. Naringin was selected as the...
08. November 2016
Abstract Among various methods for drying of pharmaceutical granules in the pharmaceutical industry, fluidized bed drying is a frequently used method due to its high rate of moisture removal, excellent performance in solids mixing, and heat and mass transfer. As pharmaceutical powders are typically organic materials with high resistivity, they can easily be charged due to repeated collision and separation of particles along with particle-wall friction in a fluidized bed dryer. This phenomenon,...
20. September 2016
Abstract Formation of core-shell nanocomposites of Fenofibrate and Itraconazole, model poorly water soluble drugs, via fluidized bed (FB) coating of their well-stabilized high drug loaded nanosuspensions is investigated. Specifically, the extent of dissolution enhancement, when fine carrier particles (sub–50 μm) as opposed to the traditional large carrier particles (>300 μm) are used, is examined. This allows testing the hypothesis that greatly increased carrier surface area and more...
24. August 2016
ABSTRACT In pharmaceutical industries, pellets are multiparticulate dosage form which was formed by the agglomeration of fine powdered excipient and drugs together that leads to the formation of small free flowing spherical or semi spherical particles. This technique is called as pelletization process. Pellets are typically varied between 500-1500 μm in size for pharmaceutical applications. It is of great interest over other similar techniques due to its uniformity of dose, less susceptibility...
12. March 2016
Objective: The objective of the current work was to develop Ivabradine hydrochloride (HCl) floating pulsatile pellets containing drug loaded calcium alginate pellets coated with pH-dependent polymer Eudragit S100 oil dispersion. Methods: Fluidized bed coating technique was used to develop pellets. A 22 factorial design was employed to study the effect of independent variables (inlet air temperature, spray rate), on dependent variables (% entrapment efficiency, % friability, and average particle...
02. May 2015
Considering the trend towards prolonged operation time of production lines (up to 24 hours), breakdowns become almost unacceptable. Hence, an almost continuous operation of the facilities has to be warranted by preventive servicing and rapid detection and repair of malfunctions. This workshop provides a fundamental introduction to the Glatt philosophy of controls, documentation and RI-diagrams and is followed by an extensive practical trouble shooting session....