07. August 2017
In this work, a fixed dose combination of gabapentin and flurbiprofen formulated as multilayer tablets has been designed, developed and in vitro and in vivo studied.
20. April 2017
Abstract Objective: The aim of this work was to investigate the potential of controlled precipitation of flurbiprofen on solid surface, in presence or absence of hydrophilic polymers, as a tool for enhnaced dissolution rate of the drug. The work was extended to develop rapidly disintegrated tablets. Significance: This strategy provide simple technique for dissolution enhancement of slowly dissolving drugs with high scaling up potential. Method: Aerosil was dispersed in ethanolic solution of...
21. March 2017
Abstract The pH-dependent solubility of a drug can lead to pH-dependent drug release from hydrophilic matrix tablets. Adding buffer salts to the formulation to attempt to mitigate this can impair matrix hydration and negatively impact drug release. An evaluation of the buffering of hydrophilic matrix tablets containing a pH-dependent solubility weak acid drug (flurbiprofen), identified as possessing a deleterious effect on hydroxypropyl methylcellulose (HPMC) solubility, swelling and gelation,...
10. January 2017
Objective: Present study aimed towards the development of a novel delivery system for pain management of rheumatic disorders. Materials and methods: An optimized solid dispersion (SD) of flurbiprofen was prepared using PEG 6000 at various ratios, of flurbiprofen and PEG 6000 i.e. 1:1, 1:2, 1:3, 1:4 and 1:5. The prepared SD formulations were optimized for solubility profile, Fourier Transform Infra-Red (FTIR) spectroscopy and differential scanning calorimetry (DSC). From IR, it may be concluded...
28. December 2016
Aim: The main objective of the present investigation was to formulate and characterize an oral pulsatile drug delivery system of flurbiprofen, for time dependent release, based on chronomodulated approach for the management of rheumatoid arthritis. Settings and Design: The drug delivery system was designed to deliver the drug with a lag time to release the drug when it could be most needful to patients of rheumatoid arthritis. Materials and Methods: Rapid release core tablets of flurbiprofen...
25. February 2016
We aimed to develop an immediate-release flurbiprofen (FLU) and esomeprazole (ESO) combination formulation with enhanced gastric aqueous solubility and dissolution rate. Aqueous solubility can be enhanced by formulating solid dispersions (SDs) with a polyvinylpyrrolidone (PVP)-K30 hydrophilic carrier, using spray-drying technique. Aqueous and gastric pH dissolution can be achieved by macro-environmental pH modulation using sodium bicarbonate (NaHCO3) and magnesium hydroxide (Mg(OH)2) as the...
16. November 2015
Flurbiprofen is a slightly water soluble, nonsteroidal anti-inflammatory active ingredient with analgesic and antipyretic activity. The purpose of this study was to develop an appropriate pellet production method for pH independent sustained release pellet formulation of flurbiprofen. Flurbiprofen pellets were produced by three different production methods; Suspension Layering, Extrusion Spherization, Rotagranulation. Although the simple and fast processing properties of Extrusion...