27. July 2016
Abstract The oral bioavailability of hydrophobic bioactives can be improved using food matrices that breakdown within the gastrointestinal tract to form colloidal structures capable of altering bioaccessibility, absorption, and/or transformation. Emulsions are particularly suitable for this purpose because their compositions, structures, and properties can be controlled, and they are already widely used in foods. The bioavailability of isolated bioactives can be improved by incorporating them...
14. June 2016
Heat sealing property of self-supporting edible films based on corn starch and a functional polysaccharide, such as amylose (AM), methylcellulose (MC) or hydroxypropylmethylcellulose (HPMC) was evaluated. Films were prepared in the laboratory by casting and heat sealed at 85–166 °C by an impulse heat sealer. Irrespective of film composition, sealing temperature influenced the seal strength. Films sealed at temperature <143 °C showed peeling mode failure attributing to weak seal strength,...
11. March 2016
While some orally delivered diabetes peptides are moving to late development with standard formulations incorporating functional excipients, the demonstration of the value of nanotechnology in clinic is still at an early stage. The goal of this review is to compare these two drug delivery approaches from a physico-chemical and a biopharmaceutical standpoint in an attempt to define how nanotechnology-based products can be differentiated from standard oral dosage forms for oral bioavailability of...
13. November 2015
The majority of pharmaceutical drugs are still produced as solid dosage forms because of the acceptability and convenience of the oral route as well as the good patient compliance it offers in general. As solid dosage forms do not require sterile manufacturing conditions, the overall production costs are less expensive. Moreover, the pharmaceutical industry has years of experience developing solid dosage forms with well-defined and known processes, equipment, and technologies. More
08. June 2015
New Workshops Continuous manufacturing in pharma A forward looking approach for the production of oral solid dosage forms Particle Engineering across the length scale From nano to macro
17. March 2015
This workshop is conceived as a supplement to our theoretical film-coating workshop, in order to explain and demonstrate potential effects on the desired functional film-coating quality, caused by rheological variations of the raw materials or changes to their chemical properties. More Information and Registration: http://www.ttc-binzen.de/cm/index.php?id=882