12. April 2017

Abstract Disintegrants are used as excipients to ensure rapid disintegration of pharmaceutical tablets and further ensure proper dissolution of the active pharmaceutical ingredient. This study investigates, disintegration mechanisms of chitin and common disintegrants. Swelling assessment (swelling force and swelling ratio) in different media; compaction behavior (pure or mixed with other excipients) tabletability, deformation (Heckel modeling) and compact disintegration times were investigated...