11. January 2018
Inhibit the fast surface crystallization of amorphous drugs with gelatin nano-coatings.
09. November 2017
Oral-solid dosage (OSD) drugs can be formulated in tablet or capsule form. Some drugs are available only as capsules or tablets, and some are available as both. Various types of capsules, with shells made of different materials, are available. When choosing a capsule type, formulators should consider factors such as the shell’s barrier to water and oxygen, reactivity, and the material it is made of.
09. June 2017
Abstract Gastroresistant capsules are obtained mostly by using modified-release fill in hard capsules, or by coating the gelatin shell with acid-resistant polymers. Modification of the material used at the stage when the capsule shell is produced would reduce the complexity and cost of introducing new products to the market. Gastroresistant gelatin films were obtained by using commercial cellulose acetate phthalate (aqueous dispersion Aquacoat® CPD). Only films casted from non-alkalized...
08. March 2017
Abstract An experimental design was established in order to optimize the mechanical properties of two oral film formulations intended for oral delivery of bioactive compounds. Carboxymethylcellulose (CMC) and gelatin type A (GelTA) were selected as polymeric matrix. Scanning electron microscopy revealed that caffeine crystals were homogeneously dispersed onto oral film matrix. Fourier-transform infrared analysis did not indicate formation of new chemical entities. USP modified dissolution assay...
29. January 2017
ABSTRACT The administration of active compounds by the oral mucosa is an efficient method for the delivery of drugs and nutrients. This work aimed to develop and characterize orally disintegrating films (ODFs) based on starch and gelatin as carriers of vitamin C. The ODFs were produced using a casting technique by varying the concentrations of starch and gelatin (0, 20, 40, 60, 80, and 100 g of starch/100 g of polymer) and were characterized in relation to contact angle, opacity, surface...
29. December 2016
Abstract Fast dissolving tablets (FDTs) have received more interest in the pharmaceutical industry for those categories of drug which show slow dissolution and less oral bioavailability. Nowadays various technologies have been developed for FDTs with improved patient compliance and convenience. FDTs tablets provide an advantage particularly for the pediatric and geriatric patients who have difficulty in swallowing and also for that who are travelling for a long and suffers from lack of water...
15. December 2016
Abstract The aim of this study was the design and evaluation of an entirely S-protected thiomer as matrix for intraorally administered films. The highly bucco-adhesive gelatin thiomer was designed based on the ligand cysteamine which was connected via disulfide bond with the aromatic leaving group 2-mercaptopyrimidine-4,6-diol (2-MPD). The thiol ligand cysteamine 2-MPD (Cys-2-MPD) was synthesized via the coupling of dimerised 2-MPD to cysteamine (Cys) and then attached to gelatin scaffold via a...
16. March 2016
During the 1950s the pharmaceutical market was flooded with oral products promising a prolonged release of actives. Since then a constantly growing effort has been devoted to the design of materials and formulations able to spatially and temporally control the release of drugs in diverse areas of the human body, finally aiming at reducing both the dosage and the frequency of the administration.
23. January 2016
This paper describes the preparation and the release properties of composite materials based on Pluronic F127 and gelatin hydrogels, which could be of interest in the field of enteral nutrition or drug administration. The composites were prepared by exploiting the opposite responsivity to temperature of a 20% w/w Pluronic F127 aqueous solution (critical gelation temperature around 23 °C) and gelatin (gel–sol temperature transition around 30 °C). More
28. September 2015
The correction to the harmonized standard for Gelatin has been approved by the Pharmacopeial Discussion Group (PDG) as described in its PDG Stage 6 Sign-Off Cover Page. Having reached Stage 6 of the PDG process, the Gelatin monograph has been formally approved by the Monographs—Excipients Expert Committee in accordance with the Rules and Procedures of the Council of Experts. More