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31. March 2017
Abstract The aim of the present study was to establish a novel polymeric excipient for liquid nasal dosage forms exhibiting viscosity increasing properties, improved mucoadhesion and stability towards oxidation in solution.In order to achieve this goal, 2-mercaptonicotinic acid was first coupled to l-cysteine by disulfide exchange reaction and after purification directly attached to the polymeric backbone of xanthan gum by carbodiimide mediated amide bond formation. The resulting conjugate was...
20. March 2017
ABSTRACT The study carried out here was focused on developing conventional monolithic controlled release matrix tablet of Atorvastatin calcium using carbomer as release controlling polymer. This system ensures the drug release at the alkaline pH region where the drug has got maximum solubility. Further the study was concentrated on comparing the impact of gelling agent polyvinyl pyrrolidone on drug release. Quality by design tools were considered during formulation development and the polymer...
23. March 2016
Recently controlled and sustained drug delivery has become the new standard in modern pharmaceutical design and a thorough research has been undertaken in achieving much better drug product effectiveness, reliability and safety. In situ gelling system has become an outstanding among novel drug delivery system (NDDS) in recent years due to its advantages like sustained and prolonged drug action, improved patient compliance and reduced frequency of administration of the drug compared to...
30. November 2015
Itraconazole (ITZ) is a broad spectrum triazole antifungal drug and commercially available as oral forms. However, effective topical forms are interesting to avoid systemic adverse effects, to directly deliver antifungal drugs to the target sites and to enhance patient compliance [1]. Microemulsion-based hydrogel (MBH), semisolid form of microemulsion (ME), is one of novel formulations practically used as topical drug carriers [2]. This study aimed to develop formulations of ITZ-loaded MBHs...