08. January 2017

ABSTRACT: In the present study, novel co-processed superdisintegrants were developed by spray drying method using microcrystalline cellulose and mannitol in different ratios (1:1, 1:2 and 1:3) for use in the fast dissolving tablet formulations. The developed excipients were evaluated for angle of repose, Carr’s index and Hausner’s ratio in comparison with physical mixture of superdisintegrants. The angle of repose of the developed excipients was found to be < 30o, Carr’s index in the...

16. November 2016

Context: Sustained release drug delivery systems are more preferred than the conventional drug delivery systems due to its enhanced bioavailability and patient compliance. Earlier studies reported on glibenclamide (GBCM) were not clear and hence, the step has been taken to explore the sustained release drug delivery system of GBCM. Aims: To evaluate the sustained release microspheres obtained of GBCM. Methods: Microspheres were prepared by ionic gelation method using the polymers like Eudragit...

24. June 2015

Formulating drugs in the amorphous form is an attractive and promising strategy to overcome the poorly water soluble challenge commonly encountered in the newly discovered drug. The active research in the investigation of the properties and performance of drugs in the amorphous form has revealed the major challenges in developing amorphous formulations into marketable products. The three main challenges are development of analytical techniques to characterise the amorphous formulations,...