05. May 2017

Many excipients are used in pharmaceutical industries for manufacture of solid oral dosage forms. Excipients are used as a bulking agents in formulation, but is should be non-reactive and enhance tabletting properties. Microcrystalline cellulose is a dried binder and native form of cellulose[1]. The development of microcrystalline cellulose (MCC) has made available to the pharmaceutical industry an extremely valuable tabletting binding agent

03. February 2017

ABSTRACT Co-processing is one of the ways to develop new excipients for the pharmaceutical industry. Co-processed excipients are a combination of established two or more excipients through physical mixing or co-process technology. Co-processed excipients has no change in chemical structure, it only changes physical properties of the final product. Co-processing technology could lead to formation of co-processed excipient with superior physical properties compared to simple physical mixtures of...

06. January 2017

Abstract Microcrystalline cellulose (MCC) HiCelTM is native from cellulose, which is manufactured from wood pulp. Microcrystalline cellulose is made by hydrolysis reaction at temperature and pressure in presence of catalyst, which acts as reaction process increment. It is neutralized after completion of hydrolysis and intended to be used as to make microcrystalline cellulose powder. HiCelTM MCC is white crystalline, free flowing powder and medium in particles size. MCC is free flowing with...

06. January 2017

ABSTRACT Metformin hydrochloride is generally used to regulate blood glucose level; It is mainly used for Insulin- dependent mellitus or Type II diabetes. Type II diabetes mellitus acts by decreasing hepatic glucose output and peripheral insulin resistance. Metformin hydrochloride is a very popular high dose pharmaceutical active. It is normally made by wet granulation method. Wet granulation is more time and man power consuming method. The overall objective of the present work was to develop...