20. April 2017

Abstract In the human organism, the circadian regulation of carbohydrates metabolism is essential for the glucose homeostasis and energy balance. Unbalances in glucose and insulin tissue and blood levels have been linked to a variety of metabolic disorders such as obesity, meta- bolic syndrome, cardiovascular diseases and type 2 diabetes. Melatonin, the pineal hor- mone, is the key mediator molecule for the integration between the cyclic environment and the circadian distribution of...