16. August 2018
Chlortetracycline hydrochloride (CTC) has been reported as having low aqueous solubility, leading to a limitation in its administration in treatments. This study demonstrated a strategy to enhance the supersaturated solubility of CTC by amorphous solid dispersion (SD). CTC-SDs were prepared with hydrophilic polymers, polyvinylpyrrolidone (PVP) and copovidone using various preparation methods: water bath evaporation, speed vacuum evaporation, and spray drying. Physicochemical properties and...
25. July 2018
Dry Powder Inhaler (DPI) could offer a propellant-free, easy-to-use powder form ensuring better stability than liquid dosae forms. Therefore the development of traditional carrier-based and carrier-free new generation systems is a determinative factor in the field of DPI formulation. The purpose of our research work was to combine these two systems, utilizing their beneficial properties to produce a novel pulmonary drug delivery system containing ciprofloxacin hydrochloride (CIP). Co-spray...
07. September 2017
Abstract Purpose: To formulate and evaluate an antispasmodic drug, mebeverine hydrochloride (Mbv-HCl), as a local anesthetic mucoadhesive buccal tablet. Methods: Mbv-HCl loaded tablets were formulated, using a direct compression technique, with varying polymer concentrations including carbopol 934P alone, carbopol 934P/hydroxypropyl methylcellulose (HPMC) mixture, or carbopol 934P/chitosan mixture. The tablets were evaluated for physicochemical characteristics, in-vitro drug release,...
20. March 2017
Abstract In the early development stage of orally disintegrating films (ODFs), suitable evaluation methods must be used. The aim of this study was to demonstrate the feasibility of using an electronic taste sensor and a flow-through cell for ODFs. A pullulan film loaded with donepezil hydrochloride (DH) was designed, as a model ODF. The film was prepared using the solution/solvent casting method. First, the dissolution profiles were compared by using a paddle method (PD) and a flow-through cell...
15. February 2017
Abstract The purpose of this study was to develop and evaluate the berberine hydrochloride (HB) - Eudragit S100 solid dispersion to prolong the drug release by expoiting its pH-sensitivity dissolution. Solid dispersion of berberine hydrochloride (HB) with Eudragit® S100 (S100) was prepared by a solvent evaporation method. Based on the evaluating dissolution in vitro, the ratio of HB and S100 was optimized to 1:4. The solid dispersion formation of HB-S100 was characterized by XRD, DSC, and...
23. January 2017
Abstract This study has investigated the potential use of zein protein from corn as a pharmaceutical excipient for formulation of oral controlled-release matrices. SMCC (silicified microcrystalline cellulose)-Prosolv® 90, SMCC HD-Prosolv® 90 HD, Avicel® PH 102 and Mannitol 60 were evaluated as co-excipients to improve the processability of zein powder. Zein/SMCC-Prosolv® 90 blend had the best flowability and tabletability. Tablets with tramadol hydrochloride, zein and SMCCProsolv® 90 were...
20. January 2017
Abstract The objective of this research activity was to formulate and evaluate Raloxifene Hydrochloride (RLX HCl) tablets (BCS class II drug) with enhanced aqueous solubility thereby achieving a formulation with improved dissolution characteristics. Tablets were prepared by incorporating excipients such as disintegrant, solubilizer, wetting agent and evaluated for various pre compression and post compression parameters. Also assay and in-vitro dissolution studies were performed. Formula RLX HCl...
06. January 2017
ABSTRACT Metformin hydrochloride is generally used to regulate blood glucose level; It is mainly used for Insulin- dependent mellitus or Type II diabetes. Type II diabetes mellitus acts by decreasing hepatic glucose output and peripheral insulin resistance. Metformin hydrochloride is a very popular high dose pharmaceutical active. It is normally made by wet granulation method. Wet granulation is more time and man power consuming method. The overall objective of the present work was to develop...
28. December 2016
Introduction: Diabetes mellitus (DM) is a worldwide disease with high mortality rate. Metformin hydrochloride has been used as the first-line drug for the treatment of DM Type 2. However, the high water solubility and short half-life lessen the potential effectiveness of using conventional metformin tablet. Floating tablet is an attractive pharmaceutical formula which can make the drugs staying with an adequate time in the absorption part of the gastrointestinal tract (i.e., the stomach), and...
20. December 2016
Abstract Salt disproportionation (a conversion from the ionized to the neutral state) in solid formulations is a potential concern during manufacturing or storage of products containing a salt of the active pharmaceutical ingredient (API) due to the negative ramifications on product performance. However, it is challenging to find an effective approach to prevent or mitigate this undesirable reaction in formulations. Hence, the overall objective of this study is to explore novel formulation...