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09. January 2016
he aim of the study was to investigate the effect of novel polymer/lipid formulations on the dissolution rates of the water insoluble indomethacin (INM), co-processed by hot melt extrusion (HME). Formulations consisted of the hydrophilic hydroxypropyl methyl cellulose polymer (HPMCAS) and stearoyl macrogol-32 glycerides—Gelucire 50/13 (GLC) were processed with a twin screw extruder to produce solid dispersions. More
01. November 2015
Highlights Development of a new biorelevant dissolution method for orodispersible films, considering mechanical force, saliva flow, volume and composition. Comparison of different conventional methods and the new biorelevant dissolution method regarding their consideration of in vivo conditions. Feasibility and problems of different dissolution setups for orodispersible films. Conventional dissolution setups show faster concentration onset compared to the new developed biorelevant setup. The...