20. April 2017

Abstract This study investigates the effects of micro-environment modification and polymer type on the in-vitro dissolution behavior and in-vivo performance of micro-environment pH modifying solid dispersions (pHM-SD) for the poorly water-soluble model drug Toltrazuril (TOL). Various pHM-SDs were prepared using Ca(OH)2 as a pH-modifier in hydrophilic polymers, including polyethylene glycol 6000 (PEG6000), polyvinylpyrrolidone k30 (PVPk30) and hydroxypropyl methylcellulose (HPMC). Based on the...

18. October 2015

14. July 2015

Telmisartan is poorly soluble in water, and the rate of dissolution, as well as bioavailability, is less. In the present study, an attempt has been made to improve the dissolution of the drug by coating the drug and carrier over sugar pellets. The solubility promoters such as alkalizes, binders and surfactants were selected to make the drug solution. The prepared pellets were evaluated for their physicochemical properties and in-vitro dissolution. The drug release rate was found to be more from...