01. October 2017
Vitamin E TPGS (TPGS) has both surfactant and P-glycoprotein (P-gp) inhibitory effects. While surfactants were previously found to cause solubility-permeability tradeoff, TPGS P-gp inhibitory effects may change this unfavorable interplay. The purpose of this research was to investigate the solubility-permeability interplay when using TPGS vs. amorphous solid dispersions (ASD) as oral drug delivery systems for the anticancer, P-gp substrate, lipophilic drug etoposide. The concentration-dependent...
15. December 2016
Abstract There is ample evidence that pharmaceutical excipients, which are supposed to be pharmacologically inactive, have an impact on drug metabolism and efflux transport. So far, little is known whether they also modulate uptake transporter proteins. We have recently shown that commonly used solubilizing agents exert significant effects on the function of organic anion uptake transporting polypeptides. Therefore, we investigated in this study the influence of frequently used pharmaceutical...
09. December 2015
Aging is the progressive deterioration of physiological functions in organisms. Folic acid (FA) can be used as antiaging. The objective of this research is the feasibility of topical delivery of FA using nanostructured lipid carriers (NLCs) to offer sustained antioxidant and antiaging effects . FA NLCS were prepared by hot high pressure homogenization. More
15. September 2015
Spray-dried dispersions (SDDs) are fascinating polymer–drug mixtures that exploit the amorphous state of a drug to dramatically elevate its apparent aqueous solubility above equilibrium. For practical usage in oral delivery, understanding how polymers mechanistically provide physical stability during storage and prevent supersaturated drugs from succumbing to precipitation during dissolution remains a formidable challenge. More
10. June 2015
Lakmini Widanapathirana , Swapnil Tale , and Theresa M. Reineke * Department of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, Minnesota 55455-0431, United States Mol. Pharmaceutics, Article ASAP DOI: 10.1021/acs.molpharmaceut.5b00202 Publication Date (Web): June 5, 2015 More
28. February 2015
Jing Zhou , Man Zhou , Fei-Fei Yang , Chun-Yu Liu , Rui-Le Pan , Qi Chang , Xin-Min Liu , andYong-Hong Liao Mol. Pharmaceutics, Just Accepted Manuscript DOI: 10.1021/mp5005838 Publication Date (Web): February 27, 2015 Copyright © 2015 American Chemical Society http://pubs.acs.org/doi/abs/10.1021/mp5005838?journalCode=mpohbp