02. April 2017
Abstract Topical drug delivery systems provide localized drug action. A hydrophilic polymer such as polyvinyl alcohol is a multi-faceted excipient that can be used as a coating agent, lubricant, stability enhancer and viscosity-increasing agent. The objective of our study was to evaluate the use of polyvinyl alcohol polymer in preparing a topical gel with a diclofenac salt as the pharmaceutical active. The gel was characterized for its rheological and other properties and its effectiveness to...
14. August 2016
Abstract Cosmetic skin care products currently in the market demonstrate an increasing trend towards antiaging products. Selection of the right formulation approach is the key to successful consumer acceptance. Nanostructured lipid carriers (NLCs) for dermal application can render added benefits to the formulation. Tretinoin a derivative of vitamin A, is a retinoid with anti-aging and anti-acne potential. The present study was aimed at formulating NLCs of tretinoin for reducing the skin...
05. March 2016
Almost all drugs are rapidly and completely absorbed form gastrointestinal tract. But some drug having problems like first pass metabolism, low bioavailability, chances of dose dumping, unstability at colonic pH, produced gastric irritation when administered in single unit dosage form or disturbed normal colonic bacterial flora. It creates the need to design safer and effective drug delivery systems. The floating microspheres are one of the most promising multiparticulates drug delivery system...
16. November 2015
See also: First in-vivo biocompatibility study of Upsalite® is published!
13. May 2015
Latanoprost is a practically insoluble prostaglandin F2α analog considered a first-line agent for glaucoma treatment. From a pharmaceutical point of view, latanoprost is challenging to be formulated as an eye drop due to its poor water solubility and the presence of an ester bond which needs to be cleaved in vivo but maintained unchanged during storage. Cyclodextrins (CDs) are known to form complexes with hydrophobic drugs... http://www.ncbi.nlm.nih.gov/pubmed/25960331