22. November 2016

Abstract Crospovidone is a commonly used tablet disintegrant. However, the synthetic disintegrant has been known to be hygroscopic and high moisture content in crospovidone used could exert deleterious effects on tablets formulated with it. The objective of this study was to elicit a better understanding between crospovidone-water interaction and its effect on disintegrant performance. Moisture sorption and desorption isotherms were obtained together with the enthalpy of immersion. Crospovidone...

14. June 2016

Two types of microparticles based on acrylic ion exchange resin were prepared and used as macro-molecular supports for the adsorption of an antibiotic (cefuroxime sodium salt) from aqueous solution. The first type of microparticles was synthesized by aqueous suspension copolymerization of acrylonitrile, ethylacrylate and ethylene glycol dimethacrylate followed by the aminolysis reaction of ternary copolymer with hydrazine hydrate. For the preparation of the second type of micro-particles the...

09. February 2016

Unintended physicochemical interaction of an excipient with a drug substance in a dosage form can result in the complexation or binding of the drug, resulting in slow and/or incomplete drug release in a dissolution medium. It is important to assess the risk whether such interactions would reduce oral bioavailability of a drug from its dosage form. This chapter describes the development of a methodology to assess the biorelevance of the drug release impact of drug-excipient binding interactions...

31. July 2015

The effects of PURE-DENT® and SPRESS® starch properties on their compression behavior was characterized using “SM2” approach (structural properties, macroscopic properties, and multivariate analysis). Moisture sorption rate constants, moisture content, amylose and amylopectin degradation enthalpy, percent crystallinity, amylose–amylopectin ratio, and cross-linking degree were used to profile starch structural properties. More