16. October 2017
Excipients, once considered as far less important than the active pharmaceutical ingredient (API) in formulated medicines, today are receiving significantly more attention from both manufacturers and regulators. Many excipient technologies are no longer considered as simply inactive ingredients.
12. January 2017
"The book edited by Drs. Vauthier and Ponchel, Polymer Nanoparticles for Nanomedicines: A Guide for their Design, Preparation and Development, represents a crucial and comprehensive work of information with highly advanced research about the construction of polymer nanoparticles." More
04. January 2017
Abstract In this study a protocol exploiting the combination of the ultrasonic atomization and the complexation between polyelectrolytes was developed to efficiently encapsulate a hydrophilic chemotherapeutic agent essentially used in the treatment of colon cancer, 5-fluorouracil, in enteric shell-core alginate-based microcarriers. The atomization assisted by ultrasound allowed to obtain small droplets by supplying low energy and avoiding drug degradation. In particular microcarriers were...
30. January 2016
This study was aimed at isolating, characterizing and evaluating the excipient functionalities of a polymer from watermelon seeds. After oil extraction, the marc was dispersed in water, agitated, filtered, the polymer harvested as the sediment in the filtrate and purified. The polymer was characterized; used as excipient in tablet formulation; and tablets' qualities were assessed using standard protocols. Physicochemical tests revealed polymer as non-polysaccharide, amorphous biomaterial with...
30. January 2016
Researchers in Germany have developed an on-dose marker technology based on polyethylene glycols (PEGs), a commonly used pharma excipient. The team describe a technique in which they incorporated combinations of PEGs within the coating of tablets to create a unique code that can be used to authenticate the dose using a liquid chromatography/mass spectrometry (LC-MS/MS) method. More
30. January 2016
Smart polymer nanogel-assisted drug delivery systems have attracted more and more attention in cancer chemotherapy because of their well-defined morphologies and pleiotropic functions in recent years. In this work, an L-cystine-crosslinked reduction-responsive polypeptide nanogel of methoxy poly(ethylene glycol)-poly(L-phenylalanine-co-L-cystine) (mPEG-P(LP-co-LC)) was employed as a smart excipient for RM-1 prostate cancer (PCa) chemotherapy. Doxorubicin (DOX), as a regular chemotherapy drug,...
29. January 2016
Abstract A simple, selective, linear, precise, and accurate RP-HPLC method was developed and validated for the Quantitation of Fingolimod Hydrochloride from bulk and formulations. Chromatographic separation was achieved isocratically on Zorbax Plus C 8 column (250×4.6 mm, 5μ particle size) using a mobile phase, Acetonitrile and Di-butyl ammonium phosphate buffer in the ratio of 45:55 v/v. The flow rate was 2.0 ml/min and effluent was detected at 198 and 100μl of sample was injected....
29. January 2016
The objective of the current research article is to provide a comprehensive review of excipients impact on the stability of the drug product and their implications during the product development. Recent developments in the understanding of the degradation pathways further impact methodologies used in the pharmaceutical industry for potential stability assessment. The formation of drug excipient adducts was very common based on the sensitive chemical moieties in the drugs and the excipients. The...
28. January 2016
Children are frequently asked to take tablets and capsules of different sizes and shapes to manage acute and chronic medical conditions. Medication size is an important factor that contributes to compliance, yet few studies detail size variation or pediatric pharmacy inventory. More
28. January 2016
Maximizing oral bioavailability of drug candidates represents a challenge in the pharmaceutical industry. In recent years, there has been an increase in the use of amorphous solid dispersions (ASDs) to address this issue, where a growing number of solid dispersion formulations have been introduced to the market. However, an increase in solubility or dissolution rate through ASD does not always result in sufficient improvement of oral absorption because solubility limitations may still exist at...