30. July 2015

A key challenge of manufacturing is variability. Variability is caused by many operational and human factors including human error, environment, wear and tear, variability in raw materials and active ingredients, and unclear procedures. It could also result from product and process design, for example, due to insufficient raw material controls and poorly defined processes. More

29. July 2015

By: Ming Huang, Research Investigator IIRobert Wethman, Senior Research ScientistJohn Wasylyk, Principal ScientistBristol-Myers Squibb More

29. July 2015

By: Joseph Kushner, IV, Ph.D.Senior Principal ScientistDrug Product DesignWorldwide Research & Development Pfizer Inc More

29. July 2015

Chitosan gelatin particles could be the ideal candidate for intraocular drug delivery due to their desirable properties. Double crosslinking in double emulsion has been used as an original and reliable method for particles preparation and their morphology has been optimized considering the main synthesis parameters such as polymers ratio, crosslinker amount, stirring speed, tensioactive amount and ionic crosslinking time, respectively. More

28. July 2015

28. July 2015

This paper presents a multiobjective design method for determining the optimal setup of excipients use processes, e.g., material reception storage testing and actual usage considering quality and cost-effectiveness. More

28. July 2015

27. July 2015

27. July 2015

Context: We previously designed, developed and characterized a novel microencapsulated formulation as a platform for the targeted delivery of Probucol (PB) in an animal model of Type 2 Diabetes. Objective: The objective of this study is to optimize this platform by incorporating Chenodeoxycholic acid (CDCA), a bile acid with good permeation-enhancing properties, and examine its effect in vitro. More

27. July 2015