28. July 2016

Brussels, 26 July 2016 EXCiPACT asbl is delighted to announce that the Nanjing DuoyuanBiochemistry Co. Ltd Chinese sitehas recently been awarded an EXCiPACT Certificate fromSGS, one of EXCIPACT’s internationally-recognised Certification Bodies. The Certificate demonstrates that the Nanjing Duoyuan Biochemistry Co. Ltdsitein Nanjing City, Jiangsu Province in PR China, manufacturespharmaceutical excipients according to the EXCiPACT Good Manufacturing Practice (GMP) Certification Standard. Its...

28. July 2016

ABSTRACT Background: Gastroretentive floating microsphere containing Lafutidine, a second generation histamine H2–receptor antagonist were prepared by ionotropic gelation technique by using sodium alginate, HPMC K4M, ethyl cellulose as polymers, sodium bicarbonate as gas generating agent and calcium chloride as cross linking agent. Objective: To formulate a system to remain in the stomach for prolonged and predictable period in order to enhance the drug bioavailability. Method: They were...

28. July 2016

Abstract Conventional alginate pellets underwent rapid drug dissolution and failed to exert colon targeting unless subjected to complex coating. This study designed coatless delayed-release oral colon-specific alginate pellets for ulcerative colitis treatment. Alginate pellets, formulated with water-insoluble ethylcellulose and various calcium salts, were prepared using solvent-free melt pelletization technique which prevented reaction between processing materials during agglomeration and...

28. July 2016

Abstract Multiparticulate formulations are composed of multiple solid dosage units which can be administered directly to the mouth or sprinkled on food. Oral grittiness (i.e. rough mouthfeel) may arise from the presence of particles in the mouth, limiting palatability. In this work, multiparticulate formulations were prepared by dispersion of spherical granules into orange flavoured vehicles thickened with hypromellose (HPMC) at different viscosities in order to assess oral perception of...

27. July 2016

Development of new products and materials, especially those which are based on renewable organic resources using innovative sustainable processes, represents an increasing interest in both academic and industrial research. Cellulose and its derivatives have demonstrated to be versatile materials with unique chemical structure which provides a good platform for the construction of hydrogel networks with distinctive properties as respects of swelling ability and sensibility to external stimuli....

27. July 2016

Granules with release-sustaining properties were developed by twin screw hot melt granulation (HMG) using a combination of stearic acid (SA) and high molecular weight polyethylene oxide (PEO) as matrix for a highly water soluble model drug, metoprolol tartrate (MPT). Earlier studies demonstrated that mixing molten SA and PEO resulted in hydrogen bond formation between hydroxyl groups of fatty acid molecules and ether groups in PEO chains. These molecular interactions might be beneficial in...

27. July 2016

Abstract Two kinds of mucoadhesive buccal tablets of clonazepam (CLZ) were developed to provide, a prolonged local or systemic delivery respectively. Tablets prepared by direct compression of combinations of different polymers were tested for swelling, erosion and residence time properties. Carbopol 971P/hydroxypropylmethylcellulose and Poloxamer/chitosan mixtures were the best and were selected for drug loading. The effect of CLZ complexation with different cyclodextrins was investigated....

27. July 2016

Abstract The aim of the presented research was the preparation and in vitro and in vivo evaluation of mucoadhesive oral films containing nystatin. Multivariate data analysis was used to evaluate an innovative approach, in which a combination of different mucoadhesive polymers was employed. The purpose of this was to assess the effects of such a combination on non-woven insoluble carmellose textile as a drug-release modifier in the structure of the film. It was observed that the mucoadhesive...

27. July 2016

Abstract The development of process analytical technologies (PAT) can improve the efficiency and product quality during pharmaceutical manufacturing. The objective of the current research was to investigate the potential application of passive acoustic emission monitoring to detect changes due to lubricant addition and its dispersal in a V-blender. Trials were conducted with sugar spheres and two placebo formulations of pharmaceutical granules in a V-blender. Vibrations from acoustic emissions...

27. July 2016

Abstract Cellulose triacetate (CTA) films were produced from cellulose extracted from sugarcane bagasse. The films were characterized using scanning electron microscopy (SEM), water vapor permeability (WVP), mechanical properties (MP), enzymatic digestion (ED), and mucoadhesive properties evaluation (MPE). WVP showed that more concentrated films have higher values; asymmetric films had higher values than symmetric films. MP showed that symmetric membranes are more resistant than asymmetric...