30. June 2017
When developing an oral liquid dosage formulation, consideration is first given to the characteristics of the active drug. The major challenges in developing oral liquid dosage forms are (i) the stability of a drug in solution, (ii) the solubility of a drug at the required level, and (iii) an acceptable taste.
30. June 2017
The purpose of this study is to evaluate the photostabilization mechanism of risperidone tablets. Risperidone is
widely used for sensory integration disorder. It is formulated as tablets, orally disintegrating tablets, fine granules,
oral solutions, and intramuscular injections.
30. June 2017
Administered by an oral route, Furosemide (FUR), a diuretic used in several edematous
states and hypertension, presents bioavailability problems, reported as a consequence of an erratic
gastrointestinal absorption due to various existing polymorphic forms and low and pH-dependent
solubility.
29. June 2017
Process Analytical Technology, or "PAT" is the term given to analytical instruments developed to measure certain attributes of product within the manufacturing process, eliminating, or substantially minimising the need for sampling for off-line analysis
29. June 2017
• Micronization of the pharmaceutical excipient tristearin by the PGSS process.
• Gaining of metastable α-forms of tristearin immediately after the processing.
• The lower the pre-expansion pressure the higher the degree of crystallinity.
• Stabilization of the metastable crystal form α in case of low pressure drops.
• Increase of transformation tendency of the metastable α-form by emulsifier
28. June 2017
The use of ammonia methacrylate copolymer as a carrier for the preparation of oral controlled-release matrix tablets containing water-insoluble drugs and investigating the effect of curing conditions.
28. June 2017
Bosentan is a dual endothelin receptor antagonist used in the treatment of pulmonary arterial hypertension (PAH). But the solubility and bioavailability of this drug are poor, which has restricted the design and development of dosage forms for efficient and successful therapy.
28. June 2017
Sustained release systems for therapeutic proteins have been widely studied targeting to improve the action of these drugs. Molecular entrapping of proteins is particularly challenging due to their conformational instability.
27. June 2017
For decades, everybody has become familiar with many brand-name and generic chemically synthesized drugs that are small molecule drug products, such as amoxicillin, Lipitor, and Crestor. Biological products, on the other hand, are practically and conceptually different as a class of therapeutic medicinal products.
27. June 2017
The International Conference on Harmonization (ICH) M9: Biopharmaceutics Classification System-based Biowaivers,1,2 was adopted in mid-June 2016. A biowaiver allows for in vitro testing to be used in lieu of in vivo bioavailability and/or bioequivalence studies to facilitate product approval, where solubility and permeability are not expected to impede bioavailability. ICH M9 will therefore minimize unnecessary in vivo studies in man and allow greater public access to vital medicines. However, t