15. January 2018
This work aims to evaluate the possible use of a poly(sodium methacrylate, methyl methacrylate) (NaPMM2) plasticized by PEG400 in design orodispersible films (ODF). Placebo ODF prepared by solvent casting were intended to study the impact of the polymer/plasticizer ratio and residual moisture on disintegration time, stickiness and mechanical properties. The drug loading capacity was assessed using ketoprofen and paracetamol.
09. January 2018
The effective surface area of drug particle is increased by a reduction in the particle size. Since dissolution takes place at the surface of the solute, the larger the surface area, the further rapid is the rate of drug dissolution. Ketoprofen is class II type drug according to (Biopharmaceutics Classification System BCS) with low solubility and high permeability.
08. November 2016
This study assesses the solid-solid interactions between the commercial form of Ketoprofen (KET), a non- steroidal anti-inflammatory drug of the propionic acid class, and several widely used pharmaceutical excipients. The work was carried out on drug-excipient mixtures, in 1:1 (w:w) ratio, blended in an agate mortar at room temperature. The compatibility/incompatibility of KET with the proposed excipients was highlighted by the most commonly used analytic methods: differential scanning...
27. July 2016
Abstract Cellulose triacetate (CTA) films were produced from cellulose extracted from sugarcane bagasse. The films were characterized using scanning electron microscopy (SEM), water vapor permeability (WVP), mechanical properties (MP), enzymatic digestion (ED), and mucoadhesive properties evaluation (MPE). WVP showed that more concentrated films have higher values; asymmetric films had higher values than symmetric films. MP showed that symmetric membranes are more resistant than asymmetric...
04. June 2016
Context Ketoprofen lysinate (KL) is one of the most widely used non-steroidal anti-inflammatory drugs in the symptomatic treatment of some chronic inflammatory diseases. Compared to ketoprofen, KL shows better pharmacokinetics and tolerability. However, due to its short half-life of 1-2 h, a multiple dose regimen is required for oral administration. Thus, the present work deals with its encapsulation in a hydrogel-based system by prilling in order to prolong its activity. Objective In this...
01. November 2015
Highlights Development of a new biorelevant dissolution method for orodispersible films, considering mechanical force, saliva flow, volume and composition. Comparison of different conventional methods and the new biorelevant dissolution method regarding their consideration of in vivo conditions. Feasibility and problems of different dissolution setups for orodispersible films. Conventional dissolution setups show faster concentration onset compared to the new developed biorelevant setup. The...
27. March 2015
Pharm Dev Technol. 2015 Mar 23:1-8. [Epub ahead of print] Comoglu T1, Inal O, Yaacoub HB. rugs exhibiting satisfactory absorption from the oral mucosa or intended for immediate pharmacological action can be advantageously formulated as orally fast-disintegrating tablets (FDTs or ODTs). .. http://www.ncbi.nlm.nih.gov/pubmed/25798913