19. June 2017

The oral route as a means of drug delivery and immunisation offers a range of advantages including ease of administration, reduced need for trained personnel to administer vaccines and generally an increased convenience and compliance.

08. March 2017

Abstract Tenofovir, currently marketed as the prodrug tenofovir disoproxil fumarate, is used clinically to treat patients with HIV/AIDS. The oral bioavailability of tenofovir is relatively low, limiting its clinical effectiveness. Encapsulation of tenofovir within modified long-circulating liposomes would deliver this hydrophilic anti-HIV drug to the reticuloendothelial system for better therapeutic efficacy. The objectives of the current study were to prepare and pharmaceutically characterize...

17. November 2016

Abstract The use of nanoparticles for drug delivery is still restricted by their limited stability when stored in an aqueous medium. Freeze drying is the standard method for long-term storage of colloidal nanoparticles; however the method needs to be elaborated for each formulation. Spray freeze drying (SFD) is proposed here as a promising alternative for lyophilizing colloidal nanoparticles. Different types of polymeric and lipid nanoparticles were prepared and characterized. Afterwards,...

30. October 2016

Abstract Liposomes are self-assembled bilayer vesicles which have attracted a great deal of interest as potential carriers for a wide range of therapeutic agents. They have significantly decreased toxicity of drugs while improving or at least maintaining their efficacy. However, their further development has been hampered by their considerable instabilities and, in some cases, providing comparable efficacy to conventional products. Decoration of liposomal nanocarriers with chitosan (CS) and its...

25. June 2016

Abstract Pharmacological pain control and management applied in this medical area represent the gold goal for anaesthesia and intensive care units. One of the most common methods for pain control is the use of opioids. However, there are a number of complications and side effects induced by prolonged systemic administration of opioids, such as nausea, vomiting, respiratory depression, drowsiness and cellular dysfunction. In order to minimize or even remove these side effects, a number of other...

02. May 2016

Introduction: Polyethylene glycol (PEG) is a polymer of choice in drug delivery systems. This USFDA-approved polymer is popular due to its tunable properties and well-established safety profile; prime requisites considered during the selection of any excipient in formulation development. Areas covered: The individual properties and applications of PEG have been discussed at length in the existing literature. However, guidance on proper selection of PEG grade to cater to one’s purpose is...

02. February 2016

Drug – delivery interaction studies were done for loperamide (Lp) loaded surfactant liposomes (LpLc) using FTIR ,DSC , XRD and SEM. Early researches have used Lp and liposomes for brain targeting programme but not have done any interaction studies .We have investigated presence of any drug degradative interactions with the excipient ( drug delivery – Liposomes) using FTIR , DSC , XRD and SEM analytical techniques. Our results suggests that presence of characteristic IR absorption peaks of...

02. December 2015