13. July 2018

Thixotropic gels, thermosoftened systems, and self-emulsifying systems have expanded the range of potential excipients. Liquid-filled hard capsules (LFHCs) are typically composed of a shell of gelatin or hydroxypropyl methylcellulose (HPMC) and filled with compatible liquids or compositions that can flow below 70 oC. LFHC technology offers several advantages over other solid dosage forms (1). It is crucial, however, to select excipients that are compatible with capsule shell integrity and...

16. January 2018

Nowadays, the pharmaceutical industry is facing an increasing numbers of low solubility drug candidates and this issue o en hinders those compounds from achieving su cient oral bioavailability. In order to alleviate this challenge, many enabling formulation technologies have been developed. Of these, liquid- lled capsules have emerged as one of the key technologies for oral drug delivery of low solubility compounds.

09. November 2017

Oral-solid dosage (OSD) drugs can be formulated in tablet or capsule form. Some drugs are available only as capsules or tablets, and some are available as both. Various types of capsules, with shells made of different materials, are available. When choosing a capsule type, formulators should consider factors such as the shell’s barrier to water and oxygen, reactivity, and the material it is made of.