04. September 2018
A decrease in the release rate over time is typically encountered when dealing with hydrophilic matrix systems for oral prolonged release due to progressive increase of the distance the drugmolecules have to cover to diffuse outwards and reduction of the area of the glassy matrix at the swelling front. In order to solve this issue, a novel formulation approach based on non-uniformdistribution of the active ingredient throughout the swellable polymer matrix was proposed and evaluated. Various...
19. July 2016
Abstract Oral disintegrating film represents an optimal alternative for delivery system of active compounds. The choice of film-forming polymer is the first step in the development of oral disintegrating films and the knowledge of molecular interactions in this matrix is fundamental to advance in this area. Therefore, this study aimed to characterize gelatin and hydroxypropyl methylcellulose (HPMC) films and their blends as matrices of oral disintegrating films. The films were produced by...
11. March 2015
Abstract Summary Two case studies were conducted to evaluate the material attributes of hypromellose (METHOCEL™ K4M premium cellulose ethers) and Starch 1500® partially pregelatinized maize starch on the performance of extended release (ER) matrices. Variations in the properties of hypromellose K4M had minimal effect on theophylline release profiles, but changes in hydroxypropyl substitution levels (% HP) and particle size of the polymer impacted the drug release from hydrochlorothiazide...