31. May 2015
By: Ben Nelson, PhD, and Chris Wilcox Trehalose is a non-reducing disaccharide consisting of two glucose molecules linked by an α,α–1,1 glycosidic bond. In the pharmaceutical industry, products that benefit from the stabilizing effects of trehalose include, but are not limited to: monoclonal antibodies (mAbs), antibody drug conjugates (ADCs), fusion proteins, peptides, stem cells, and vaccines. Table 1 is a brief list of drugs that include trehalose as a component of their formulations....
31. May 2015
Hydroxypropyl-β-cyclodextrin (HP-β-CD) is being explored as excipient for administration of poorly soluble NCE's in pediatrics. In support of pharmaceutical development, non-clinical studies were performed to investigate whether oral and intravenous administration of HP-β-CD showed a different response in juvenile rats versus adult rats. Read more
31. May 2015
The present article contains a brief review on various formulation approaches used in controlled release drug delivery system, the role of polymers in controlled delivery of many fast release drugs and the mechanism of drug release form these polymeric matrices. Read more
31. May 2015
Dissolution of poorly water-soluble drug, Artemisinin (ART), was enhanced by encapsulating the drug particles inside pore channels of ordered mesoporous silica, SBA-15, via co-spray drying. Read More: http://informahealthcare.com/doi/abs/10.3109/02652048.2015.1035684
31. May 2015
Effective delivery of drugs to alveoli in a controlled manner using hydrophobic polymers as carriers has already been reported. Preclinical studies revealed that toxicity and hydrophobicity are related to each other in pulmonary delivery. Read more
31. May 2015
IPEC Europe's board has responded to member feedback in our recent survey and drawn up a document detailing its priorities over the next five years. Read more
28. May 2015
See also: http://www.colorcon.com/news/corp/Press%20Releases/EXCIPACT-CERTIFICATION_UK-2015.pdf