18. October 2017
WR Grace & Co has licensed rights to a bioavailability enhancement technology from Formac Pharmaceuticals NV.
01. October 2017
Orally disintegrating tablets (ODTs) are becoming increasingly important in the global pharmaceutical market for both prescription and over-the-counter medications because they can significantly improve patient compliance. They can be swallowed without the need for water, are generally smaller, and have good mouthfeel. Such properties make ODTs particularly convenient for children and the elderly, especially when a flavor is also incorporated into the formulation. In addition, they are the...
30. August 2017
Chemotherapy is the most common therapeutic strategy for the treatment of unresectable hepatocellular carcinoma. However, the therapeutic efficacy is limited by low delivery efficiency of chemotherapeutics and severe toxicity towards healthy tissues.
11. August 2017
The goal of this study was to test the feasibility to load non-ordered, non-spherical mesoporous silica with the model drug paracetamol, and subsequently coat the loaded particles using one single pilot scale fluid bed system equipped with a Wurster insert. Mesoporous silica particles (Davisil®) with a size ranging from 310 to 500 μm and an average pore diameter of 15 nm were loaded with paracetamol to 18.8% drug content. Subsequently, loaded cores were coated with ethylcellulose to obtain...
07. June 2017
Accessing mesoporous and nanostructure biomaterial information can be particularly time consuming and problematic due to the interdisciplinary nature of the field. Relevant papers can be found across a broad range of journals and various key words are needed to comprehensively retrieve information. A keyword lexicon and themed bibliography of over 250 review articles from more than 100 different journals has therefore been assembled to aid students and researchers in this expanding eld. Reviews...
07. June 2017
In this work, the focus was to investigate the possibilities of using a mesoporous type of magnesium carbonate to stabilize the amorphous state of different APIs. Due to the nanometer sized pores in the material, complete conservation of amorphous APIs was obtained.
23. March 2017
Abstract The pharmaceutical industry has seen an increased need of carriers or excipients design that allows the controlled release of a drug in the human body. The main role of an excipient is to carry the drug for its administration under therapeutic index. Among the new generation of excipients, the ordered mesoporous silica (MS) presents several advantages, such as excellent biocompatibility, good adsorption capacity, and precise control in the drug delivery. However, the high cost of...
12. February 2017
Abstract This study describes the application of three non-ordered mesoporous silicas (Syloid AL-1, Syloid 72 and Syloid 244) in improving the dissolution rate of a poorly aqueous soluble drug, namely gemfibrozil. For this purpose, solid dispersions were formulated using a robust and controlled microwave heating method. Prepared formulations were subjected to solid state characterisation and dissolution behaviour. Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) results...
02. February 2017
Abstract Drug release from mesoporous silica systems has been widely investigated in vitro using USP Type II (paddle) dissolution apparatus. However, it is not clear if the observed enhanced in vitro dissolution can forecast drug bioavailability in vivo. In this study, the ability of different in vitro dissolution models to predict in vivo oral bioavailability in a pig model was examined. The fenofibrate-loaded mesoporous silica formulation was compared directly to a commercial reference...
26. September 2016
Abstract Formulating poorly water soluble drugs using ordered mesoporous silica materials is an emerging approach to tackle solubility-related bioavailability problems. The current study was conducted to assess the bioavailability-enhancing potential of ordered mesoporous silica in man. In this open-label, randomized, two-way cross-over study, 12 overnight fasted healthy volunteers received a single dose of fenofibrate formulated with ordered mesoporous silica or a marketed product based on...