24. February 2017

Lipid-based formulations (LBFs) can be effective drug delivery systems for poorly watersoluble chemical entities, provided they are designed with careful selection of the excipients, based on their role in the delivery system and in relation to the API properties. The primary factor leading to increased bioavailability by LBFs is the administration of the drug in a pre-dissolved state thus avoiding the dissolution limiting step. The fate of a drug formulated in a LBF is dependent on the ability...