20. April 2017

Abstract In the human organism, the circadian regulation of carbohydrates metabolism is essential for the glucose homeostasis and energy balance. Unbalances in glucose and insulin tissue and blood levels have been linked to a variety of metabolic disorders such as obesity, meta- bolic syndrome, cardiovascular diseases and type 2 diabetes. Melatonin, the pineal hor- mone, is the key mediator molecule for the integration between the cyclic environment and the circadian distribution of...

18. October 2016

ABSTRACT The goal in drug delivery research is to meet therapeutic needs relating to particular pathological conditions by developing new formulations. Research in the chronopharmacological field has demonstrated the importance of biological rhythms in drug therapy, and this has brought a new approach to the development of oral drug delivery systems. Chronotherapeutics is the discipline concerned with the delivery of drugs according to the intrinsic activities of a disease over a certain period...