29. September 2017

A key point in the administration of biopharmaceuticals is the recognition of appropriate, effective, safe and biocompatible nanocarriers allowing overcoming extracellular and intracellular biological barriers without loss of drug stability and adequate therapeutic response at the target sites.

22. May 2017

Mesalazine also known as mesalamine (5-aminosalicylic acid) is the amino deriva- tive of salicylic acid, this molecule possesses an amphoteric character due to the pres- ence of the carboxyl and amino groups. So; the value of the pH medium has a strong effect on its solubility and protonation.

21. February 2017

Abstract In order to improve the encapsulation process, a newly supercritical antisolvent process was developed to encapsulate fish oil using hydroxypropyl methyl cellulose as a polymer. Three factors, namely, temperature, pressure, and feed emulsion rate were optimized using response surface methodology. The suitability of the model for predicting the optimum response value was evaluated at the conditions of temperature at 60°C, pressure at 150 bar, and feed rate at 1.36 mL/min. At the...

13. January 2017

Abstract Several studies have demonstrated differences among strains of probiotic bacteria with regard to their survival in acid environment. Probiotics must survive in gastric acids to reach the small intestine and colonize the host for appropriate prevention and management of several gastrointestinal diseases. To improve the survival rates of probiotic microorganisms during gastric transit, microencapsulation is considered to be a promising process. A variety of polymers are commonly used for...

20. November 2016

Abstract Associating protein with nanoparticles is an interesting strategy to improve their bioavailability and biological activity. Solid lipid nanoparticles (SLN) have been sought as carriers for therapeutic proteins transport to the lung epithelium. Nevertheless, because of their low inertia, nanoparticles intended for pulmonary application usually escape from lung deposition. To overcome this problem, the production of spray-dried powders containing nanoparticles has been recently reported....

20. November 2015

Taste-masking techniques are applied to mask or overcome the bitter or unpleasant taste of active pharmaceutical ingredients/drugs to achieve patient acceptability and compliance. Oral administration of bitter or unpleasant tasting drugs is often the biggest barrier for patient groups, such as pediatrics and geriatrics. More See also

28. October 2015

Introduction: Choline bitartrate (CBT) is a vital nutrient for fetal brain development and memory function. It is hygroscopic in nature which is associated with stability related problem during storage such as development of fishy odor and discoloration. Aim: Microencapsulation method was adopted to resolve the stability problem and for this hydrogenated soya bean oil (HSO) was used as encapsulating agent. More

27. July 2015

Context: We previously designed, developed and characterized a novel microencapsulated formulation as a platform for the targeted delivery of Probucol (PB) in an animal model of Type 2 Diabetes. Objective: The objective of this study is to optimize this platform by incorporating Chenodeoxycholic acid (CDCA), a bile acid with good permeation-enhancing properties, and examine its effect in vitro. More

18. February 2015

This study investigates the use of microencapsulation by fluidised bed coating for the protection of ascorbic acid during long-term storage under simulated tropical conditions. Microencapsulation materials, loading levels, fluidised bed processing conditions and the results of storage trials were evaluated. Cellets® 350 is a suitable base material, whereas sugar spheres are not suitable due to agglomeration and bed collapse during processing. Sodium alginate provided the best overall...