02. May 2017

The multiparticulate drug product concept covering micropellets, pellets and mini-tablets is presented as a highly feasible approach to present convenient and patient friendly medication for the geriatric population. Improved swallowability and optimized administration regimen going along with defined drug dosage are achievable. Extemporaneous preparation of medicines from standard medication can be avoided going along with improved patient safety.

22. April 2017

Abstract Mini-tablets have potential applications as a flexible drug delivery tool in addition to their generally perceived use as multi-particulates. That is, mini-tablets could provide flexibility in dose finding studies and/or allow for combination therapies in the clinic. Moreover, mini-tablets with well controlled quality attributes could be a prudent choice for administering solid dosage forms as a single unit or composite of multiple mini-tablets in patient populations with swallowing...

26. October 2016

Abstract The multiparticulate drug product concept covering micropellets, pellets, and mini-tablets is presented as a highly feasible approach to present convenient and patient friendly medication for the geriatric population. Improved swallowability and optimized administration regimen going along with defined drug dosage are achievable. Extemporaneous preparation of medicines from standard medication can be avoided going along with improved patient safety. With one multiparticulate pellet,...

02. August 2016

Highlights • Carnauba wax was exploited as a novel excipient for melt granulation. • Melt granulation improved tabletability and flowability of both captopril and metformin HCl. • Sustained release of captopril was achieved by Ethocel™ at a 50% (w/w) concentration. • Sustained release of metformin HCl was reached by film-coating (Kollicoat® SR 30D: Opadray® II). • Carnauba wax assisted sustaining the drug release in conjunction with the polymers. More