22. November 2017
Continuous efforts to improve performance of drugs via incorporation in particulate and soft colloidal carriers have introduced new functional categories of excipients. These excipients are used to protect drugs, modify their release, and increase their bioavailability and/or selectivity for target tissues with the aim to improve patient compliance, and therapeutic outcomes.
27. July 2016
Abstract The oral bioavailability of hydrophobic bioactives can be improved using food matrices that breakdown within the gastrointestinal tract to form colloidal structures capable of altering bioaccessibility, absorption, and/or transformation. Emulsions are particularly suitable for this purpose because their compositions, structures, and properties can be controlled, and they are already widely used in foods. The bioavailability of isolated bioactives can be improved by incorporating them...
14. November 2015
Highlights • Cilostazol has low oral bioavailability due to poor aqueous solubility. • Cilostazol was loaded in nanoemulsion formulations. • Developed formulation possessed good physical stability. • Drug loaded nanoemulsion enhances permeation of drug through membrane. • Nanoemulsion showed increase in oral bioavailability of drug. More