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08. June 2017
Extruded milled griseofulvin (GF, drug) suspensions along with additional polymers.
• Formed HPC-based nano composite and Soluplus-based amorphous solid dispersion (ASD).
• Compared dissolution response under non-supersaturating conditions (low drug dose).
• Drug nanocrystal in the nano composite dissolved faster than amorphous drug in ASD.
• Showed the impact of drug particle size and extrudate (matrix) size on dissolution.