22. September 2018
Zein is the main storage protein of corn and it has several industrial applications. Mainly in the last 10–15 years, zein has emerged as a potential pharmaceutical excipient with unique features. Zein is a natural, biocompatible and biodegradable material produced from renewable sources. It is insoluble, yet due to its amphiphilic nature, it has self-assembling properties, which have been exploited for the formation of micromicroparticle and nanoparticle and films. Moreover, zein can hydrate...
07. July 2018
In this study, a process map was developed in an effort to improve the understanding of dry granulation of pharmaceutical excipients by roll compaction process, and to implement the quality-by-design (QbD) approach. Through development of the process map, a correlation was made between the critical process parameters (roll pressure, screw speed), and critical quality attributes (density of ribbons and granule size). This method reduces development time, quantity of materials required and cost....
15. May 2018
Zein is the main storage protein of corn and it has several industrial applications. Mainly in the last 10–15 years, zein has emerged as a potential pharmaceutical excipient with unique features. Zein is a natural, biocompatible and biodegradable material produced from renewable sources. It is insoluble, yet due to its amphiphilic nature, it has self-assembling properties, which have been exploited for the formation of micromicroparticle and nanoparticle and films. Moreover, zein can hydrate...
06. September 2017
Abstract This review summarizes recent progress of the robust and smart hydrogels prepared from natural polymers including polysaccharides, proteins, etc. These hydrogels exhibit outstanding mechanical properties due to their nanofibrous aggregated microstructures and special crosslinking networks. Furthermore, these hydrogels show some smart stimuli-responsive behaviors triggered by pH, temperature, light, electricity and magnetism. Hopefully, these hydrogels derived from natural polymers with...
08. January 2017
ABSTRACT: The aim of the present work was to prepare and evaluate fast dissolving tablets of nebivolol with a view to enhance patient compliance and minimize the side effects. In this study, fast dissolving tablets of nebivolol were formulated by direct compression method using mucilages of tapioca seeds (Manihot esculenta), basella climb (Basella alba), red sorrel (Hibiscus sabdariffa) as natural disintegrants and crosspovidone as a synthetic superdisintegrant in different ratios with directly...
17. November 2016
Abstract Most ophthalmic illnesses are treated by topical administration of drug in the form of conventional dosage forms (solutions, suspensions, or ointments). In spite of remarkable patient compliance, these dosage forms suffer from the issues of poor ocular bioavailability due to pathophysiological barriers prevailing in the eye. In recent decades, numerous efforts have been made to advance ophthalmic drug delivery including the one adopted to prolong the residence time of drug in the...
01. October 2016
Abstract Current polymeric research has explored various applications in drug delivery and its related biomedical applications. Natural polymers especially those are derived from plant sources has evidenced for growing interest and attention in biomedical and pharmaceuticals sectors. Owing to their relative abundance, low cost, and biodegradable and eco-friendly profiles, plant derived polysaccharides are more preferred over the synthetic polymers. Present work demonstrates the drug delivery...
14. April 2016
For many years chitosan has been the subject of interest for its use in different medical fields due to its appealing properties such as biocompatibility, biodegradability, low toxicity and relatively low production cost from abundant natural sources. Chitosan is positively charged at low pH values, so it is spontaneously associated with negatively charged polyions in solution to form polyelectrolyte complexes. These chitosan based polyelectrolyte complexes exhibit favourable physicochemical...
04. February 2016
Orally disintegrating films (ODFs) can transport natural active compounds such as hydrolyzed collagen (HC) and ethanol extract of propolis (EEP). This paper aimed to investigate the effect of lecithin on different gelatin and HC polymeric matrices with addition of EEP. ODFs were prepared by casting and were characterized (color parameters, water content, mechanical properties, microstructure, disintegration time (DT), infrared spectroscopy (FTIR), contact angle (CA), swelling degree and total...
03. February 2016
The chairs of each of the 8 Special Interest Groups of the Board of Pharmaceutical Sciences of the International Pharmaceutical Federation have compiled opinions with regard to major challenges for the pharmaceutical sciences over the next 5-10 years. Areas covered are drug design and discovery, natural products, formulation design and pharmaceutical technology, pharmacokinetics /pharmacodynamics and systems pharmacology, translational and personalized medicine, biotechnology, analytical...