27. September 2017
everal medicines frequently used in neonates and infants contain potentially harmful excip-ients like ethanol, propylene glycol (PG), methyl-and propyl-parabens. Especially preterm neonates may bechronically exposed as a result of being poly-medicated for extended periods.
07. February 2017
INTRODUCTION: The pharmacokinetics of excipients in neonates differs from that of older children. In a recent pan--European survey, two thirds of neonates received at least one potentially harmful excipient, such as ethanol and benzoates. The content of sweeteners varied by route of administration (more common by enteral than parenteral route), and regional differences were revealed. The survey did not identify if the content of excipients was more pronounced in medications prescribed for...
10. September 2015
Neonates are given many medicines. A significant proportion of these medicines contain excipients. Excipients are used to facilitate the manufacture and use of medicines. Without excipients, it would not be feasible to formulate some drugs into appropriate medicinal products. More
05. March 2015
Current treatment for adrenal insufficiency in neonates and infants is unsatisfactory as unlicensed adult formulations are used and the minimum unit dose available is a scored 5mg hydrocortisone tablet. These are difficult to administer to neonates and give rise to inconsistencies in dose as content uniformity of crushed tablets cannot be verified. We have developed a new formulation, Infacort®, specifically designed for infants and neonates… more...