25. March 2018
Hydrogels are a unique class of three dimensional cross-linked polymeric networks that can hold a large fraction of aqueous solvents and biological fluids within their structures. Nowadays, hydrogels have attracted a growing interest of many scientists in different fields of research. Intelligent hydrogels have found a significant role in a wide variety of applications such as drug delivery systems, tissue engineering, optics, diagnostics and imaging. The purpose of this paper is to present a...
14. February 2017
Abstract Dry granulation using roll compaction is a typical unit operation for producing solid dosage forms in the pharmaceutical industry. Dry granulation is commonly used if the powder mixture is sensitive to heat and moisture and has poor flow properties. The output of roll compaction is compacted ribbons that exhibit different properties based on the adjusted process parameters. These ribbons are then milled into granules and finally compressed into tablets. The properties of the ribbons...
08. June 2016
Purpose: Pharmaceutical industry is tightly regulated owing to health concerns. Over the years, the use of computational intelligence (CI) tools has increased in pharmaceutical research and development, manufacturing, and quality control. Quality characteristics of tablets like tensile strength are important indicators of expected tablet performance. Predictive, yet transparent, CI models which can be analysed for insights into the formulation and development process. Methods: This work uses...