11. January 2018
Inhibit the fast surface crystallization of amorphous drugs with gelatin nano-coatings.
14. September 2017
Sustained-release formulations have been widely developed to improve the therapeutic performance of drugs, in particular, to increase pharmacological efficacy and reduce side effects.
25. February 2017
Abstract Halloysite nanotubes, a biocompatible nanomaterial of 50–60 nm diameter and ca. 15 nm lumen, can be used for loading, storage and sustained release of drugs either in its pristine form or with additional polymer complexation for extended release time. This study reports the development composite tablets based on 50 wt.% of the drug loaded halloysite mixed with 45 wt.% of microcrystalline cellulose. Powder flow and compressibility properties of halloysite (angle of repose, Carr’s...
21. June 2016
Aims Food intake is known to have various effects on gastrointestinal luminal conditions in terms of transit times, hydrodynamic forces and/or luminal fluid composition and can therefore affect the dissolution behavior of solid oral dosage forms. The aim of this study was to investigate and detect the dosage form-dependent food effect that has been observed for two extended-release formulations of nifedipine using in vitro dissolution tests. Methods Two monolithic extended release formulations,...
02. June 2016
In this study, osmotically controlled drug delivery system of Nifedipine using different polymers were formulated. Nifedipine, is an anti-hypertensive drug. It acts as a calcium channel blockers. Unlike any other conventional dosage forms in osmotic system, the mechanism involved is osmosis. In the present studies, the release of the drug is porosity.A total of nine formulations were prepared by using the different polymers (Poly Ethylene oxide, HPMC K15 M and Ethyl cellulose) in different...
04. March 2016
The main purpose of this study was to increase the solubility of poorly soluble drug by preparing solid dispersions. Nifedipine (poorly water soluble drug), when prepared as solid dispersion showed increased solubility and dissolution rate. Solid dispersions of Nifedipine were prepared by using silsol 6035 as carrier in various proportions 10%, 20% and 30% by solvent loading (solvent droplet addition)method and various grades of silica by co-milling method in ratios of (1:1, 1:2 and 2:1). The...
23. February 2016
The aim of this study was firstly to evaluate the utility of Hybrane S1200 as a hot melt extrusion (HME) carrier to prepare instant-release multiparticulate systems for very poorly-soluble drugs such as ketoconazole or nifedipine. Hybrane S1200 allows an easy extrusion of its drug mixtures at a relatively low temperature, not higher than 90 °C, and with no need of any additional aid. Extrudates containing 10% of nifedipine or ketoconazole form monophasic systems. Nifedipine extrudate shows no...
17. December 2015
The present study investigates the enhancement of the dissolution rates for poorly-water soluble drugs by a new adsorption method. The results show that the current adsorption method enhanced the dissolution rate of both nifedipine and indomethacin to a significant extent by nano-confinement of drugs into the pore spaces of highly-porous excipients. More
22. September 2015
Grace Syloid® XDP silica is an advanced excipient designed to carry PEG co-solvent based drug delivery strategies. The unique morphology and properties of this silica make it a great choice for creating free flowing powders that can be processed into capsules or tablets so that these poorly soluble drugs can be delivered in a convenient, stable oral form. More