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08. February 2016
Protamines are a group of highly basic peptides which is sometimes added to insulin formulations to prolong the pharmacological action. In this study, different methods were investigated in order to identify protamine in insulin formulations. Capillary electrophoresis in aqueous and non-aqueous media was tested to separate these peptides with very close amino acid sequences. Different buffers (phosphate or formate, both acidified) and various additives (principally negatively charged and...
08. August 2015
The present study involved the use of old biomaterial starch as excipient for oral controlled drug delivery in which the properties of starch are tailored by chemical modification. Among the various commercially available starches, high amylose starch (HAS) was chosen and chemically modified ... More