30. November 2015
Multiparticulate dosage forms are a recent strategy to meet the special needs of children, elderly people and patients suffering from dysphagia. Our study presents a novel and cost-efficient approach for the manufacturing of a taste-masked multiparticulate system with a stable immediate release profile by applying lipid-based excipients in a solvent-free hot melt coating process. More
30. November 2015
Pharmaceutical solid dosage forms are commonly coated to modify the release of drugs. Due to the disadvantages of coated single-unit dosage forms, such as occurrences of dose dumping and local irritation, coated multi-particulates are preferred. Coated multi-particulates can eventually be filled into capsules or compressed into tablets. The latter is more desirable as unit production costs of tablets are considerably lower and machinery more easily available. More
30. November 2015
As one of the possible technologies to improve the oral absorption of poorly water-soluble drugs, supersaturable formulation is now attracting the attention which enables to dissolve the drug to the higher concentration than their equilibrium solubility [1]. Those include salt-formation, solid-dispersion, co-crystallization or the use of amorphous form. Since supersaturation is a thermodynamically metastable state, supersaturated solution has a high potential to precipitate. More
30. November 2015
Itraconazole (ITZ) is a broad spectrum triazole antifungal drug and commercially available as oral forms. However, effective topical forms are interesting to avoid systemic adverse effects, to directly deliver antifungal drugs to the target sites and to enhance patient compliance [1]. Microemulsion-based hydrogel (MBH), semisolid form of microemulsion (ME), is one of novel formulations practically used as topical drug carriers [2]. This study aimed to develop formulations of ITZ-loaded MBHs...
30. November 2015
The floating drug delivery system (FDDS) has become increasingly attractive system for gastroretentive dosage forms because it can prolong gastric retention time and improve drug bioavailability [1]. Using low density material of polypropylene foam powder is one of interestingapproach forFDDS development.This floating system has initial low density so it can float immediately without lag time. More
29. November 2015
Counterfeit drugs are a major threat to public health. Current efforts focus on serialization of the secondary packaging which do not allow to trace the individual unit. As a proof of concept, we intended to mark each tablet for its unambiguous recognition. More
29. November 2015
The present invention relates to pharmaceutical formulations of active ingredients which have low solubility in aqueous solutions, having improved release of active ingredient, and to a process for the preparation thereof. In particular, these are pharmaceutical preparations in which magnesium hydroxide carbonate serves as excipient. More
29. November 2015
An increasing number of newly discovered drugs are poorly water-soluble and the use of natural and synthetic lipids to improve the oral bioavailability of these drugs by utilizing the digestion pathway in-vivo has proved an effective formulation strategy. The mechanisms responsible for lipid digestion and drug solubilisation during gastrointestinal transit have been explored in detail, but the implications of drug precipitation beyond the potential adverse effect on bioavailability have...