31. October 2017
Drug loaded dendritic core-multishell (CMS) nanocarriers are of especial interest for the treatment of skin diseases, owing to their striking dermal delivery efficiencies following topical applications. CMS nanocarriers are composed of a polyglycerol core, connected by amide-bonds to an inner alkyl shell and an outer methoxy poly(ethylene glycol) shell.
30. October 2017
The purpose of this work was to investigate the effect on the dissolution behavior when silica was added in different ways. The solid dispersion was prepared by hot-melt extrusion (HME) using indomethacin (IND) as a model drug and Kollidon VA64 as a carrier.
30. October 2017
Coenzyme Q10 (CoQ10) is an antioxidant substance indicated as a dietary supplement which has been proposed as adjuvant in the treatment of cardiovascular disorders and cancer for its protective and immunostimulating activities.
30. October 2017
Understanding properties and mechanisms that govern drug degradation in the solid state is of high importance to ensure drug stability and safety of solid dosage forms. In this study, we attempt to understand drug–excipient interac-tions in the solid state using both theoretical and experimental approaches.
30. October 2017
Omeprazole is a pro-drug that accumulates in the acid space of the parietal cell where it is transformed to the active state. However the drug has several characteristics which determine its access to this site of action. Omeprazole is a weak base which is stable at neutral pH but decomposes rapidly in an acidic environment.
29. October 2017
In oral drug delivery modi ed release dosage forms (MRD) plays an important role in regulating the drug delivery to improve the quality of therapy. One excellent technique to formulate MRDs is multiple unit particle systems (MUPS), where the dosage form is distributed over multiple units rather than a single unit.
29. October 2017
Jellies for oral administration are non- owable gelatinous preparations having a certain shape and size. This dosage form is being explored for applications for pediatric patients and other populations like geriatric and dysphagic patients. It has several advantages over liquid dosage forms in term of palatability, patient acceptance, suitability for controlled release applications and stability.
28. October 2017
The goal of study was to formulate and characterize pullulan based oral thin film (OTF) of zolmitriptan by solvent casting method. Based on preliminary trials, glass, PEG 400 and sucralose were selected as casting surface, water-miscible plasticizer and sweetener for OTF, respectively. A 32 factorial design was used to study the effect of amount of PEG 400 (X1) and sucralose (X2) as independent variables on tensile strength (Y1), elasticity (Y2), % in-vitro drug release in phosphate buffer of...
27. October 2017
Polar, hydrophilic natural and synthetic polymers physically or chemically cross-linked into 3D-network and bonding a large amount of water (up to 100 g/g or higher), but insoluble in water are known as hydrogels (HG, water containing gels). The insolubility of HG in water is of importance for preservation of the system integrity.
27. October 2017
IPEC Europe has published an informative overview on the value of excipients in the pharmaceutical industry, in medicines and finally for the patients.