27. August 2018
Lipid excipients for oral drug delivery include high to low HLB solubility and bioavailability enhancers, lubricants, modified-release, taste-masking and API protection agents. Excipients are used in a variety of processes enabling the formulation of different dosage forms, mainly tablets and granules; hard and soft capsules. For information on excipient functionality and formulation with different processes please see the Formulation Technologies section.
06. April 2018
The development of effectively formulated oral drug products is key to ensuring patient compliance and desired clinical outcomes. Given the increasing regulatory expectations for the development of bespoke age-appropriate products, critical performance features now include palatability and overall acceptability in addition to standard drug-delivery requirements for oral medications. Understanding and modifying the taste attributes of aversive drug substances is, therefore, important. There are...
04. December 2017
Oral drug delivery remains the preferred method of administration but BCS Class II drugs are not ideally suited to this due to their inherent poor solubility. Although a number of methods to increase solubility already exist, there is a need for manufacturing methods which are more flexible to the requirements of the individual patient.
07. August 2017
A suitable dissolution test as a surrogate for in vivo absorption is highly attractive in the early stage of formulation development. Ideally, changes in dissolution in vivo should be reflected by the corresponding in vitro release. However, conventional dissolution tests have limitations to address this need due to the lack of biorelevance.
03. August 2017
Abstract Ink-jet printing is a precise and versatile technique that accurately deposits small volumes of solutions (pico litres) in specific locations. Recently inkjet printing has attracted increasing attention in the pharmaceutical industry because of its ability to deliver low adjustable doses, variable drug release profiles and drug combinations suitable for the paradigm of personalised medicines. The significant growth in the aging population and the rise in the number of patients...