02. July 2018
Palatability and patient acceptability are critical attributes of dispersible tablet formulation. Co-processed excipients could provide improved organoleptic profile due to rational choice of excipients and manufacturing techniques. The aim of this study was to identify the most suitable co-processed excipient to use within directly compressible dispersible tablet formulations. Nine excipients, selected based on successful manufacturability, were investigated in a randomised, preference and...
24. December 2017
Drug therapy for children is one of the cornerstone developments that have sharply reduced childhood mortality. Despite this, many challenges remain in ensuring that children receive safe and effective drug therapy. There are unique issues in treating children with oral medication relating to development, existing formulations and medication acceptability. Medication acceptability in children is complex relating to a wide range of factors, including drug palatability.
12. November 2017
Taste masking increases drug acceptability and medication adherence in pediatric, geriatric, and other special patient populations.
11. August 2016
Many pediatric patients require medications that are not available in age appropriate formulations, especially those with cardiovascular diseases. The use of a suitable vehicle is critical for the preparation of extemporaneous formulations with the expected effect. Considering that palatability is essential to treatment adherence in children, we analyzed the acceptance of extemporaneous formulations of Captopril and Furosemide prepared using a developed vehicle in three flavors: neutral,...
13. April 2016
The purpose of this review is to discuss the advantages and limitations of taste sensors in the evaluation of the taste of palatability of different oral dosage forms. Firstly, we consider some ways in which the palatability of various pharmaceutical formulations including orally disintegrating tablets (ODTs), are tested using two different taste sensors. Secondly, we focus on the evaluation of palatability of ODTs. We compare the usefulness of three pieces of apparatus for estimating the...
24. September 2015
Palatability studies are required for new medicines to ensure that they are acceptable to children. However, there is no gold standard method to conduct such studies. More