01. June 2017

Amorphous solid dispersions (ASD) are a common formulation approach for orally delivered small molecule active pharmaceutical ingredients (APIs) whose oral bioavailability (BA) is limited by dissolution rate and/or solubility in the gastrointestinal tract. Some of the foremost reasons this method has become so prevalent are the large potential for gains in bioavailability, easily assessable and mature manufacturing platforms, and straightforward integration of the resultant dispersions into an...