08. March 2017
ABSTRACT: Topiramate (TPM) is effective for multiple seizure types and epilepsy syndromes in children and adults. Topiramate has adverse effects (including cognitive, depression, renal stones), but many of these are low incidence when started at a low dose and slowly titrated to 100 to 200 mg/day. Also, TPM has proven benefit for migraine, obesity, eating disorders, and alcohol use disorders, which can be comorbid in patients with epilepsy and may also be effective in subpopulations within...
10. October 2016
Abstract A lack of evidence to guide the design of age-appropriate and acceptable dosage forms has been a longstanding knowledge gap in paediatric formulation development. The Children’s Acceptability of Oral Formulations (CALF) study captured end-user perceptions and practices with a focus on solid oral dosage forms, namely tablets, capsules, chewables, orodispersibles, multiparticulates (administered with food) and mini-tablets (administered directly into the mouth). A rigorous development...
24. June 2016
Abstract The term “patient centered,” “patient centric,” or “patient centricity” is increasingly used in the scientific literature in a wide variety of contexts. Generally, patient centric medicines are recognized as an essential contributor to healthy aging and the overall patient’s quality of life and life expectancy. Besides the selection of the appropriate type of drug substance and strength for a particular indication in a particular patient, due attention must be paid that...
24. May 2016
The present investigation is an attempt to design and evaluate rapidly dissolving oral strips of metoprolol succinate, an anti-hypertensive agent. Rapidly dissolving oral strips were prepared by solvent casting technique using hydroxyl propylmethylcellulose-5 cps and polyvinyl alcohol as the lm forming polymers. The prepared strips were evaluated for the characteristics such as thickness, folding endurance, percent elongation, tensile strength, surface pH, percent drug content, in-vitro...
01. May 2016
Objective: Tablet is still most popular conventional dosage forms existing today, but the drawback of solid dosage forms is the difficulty in swallowing (dysphagia) or chewing in some patients particularly pediatric and geriatric patients. For this reason, orodispersible tablets (ODT) that can rapidly dissolve or disintegrate in the oral cavity have attracted a great deal of attention. The main objective of this review is to explore various methodologies for masking the taste of obnoxious...
22. March 2016
An increasing elderly population is leading to a change in the global demographics. This presents a new challenge to society and the pharmaceutical industry. This demographic shift is providing an opportunity for the pharmaceutical industry to meet the specific needs of the changing patient population. One issue that has been identified is defining what is meant by “an older patient”, since this definition cannot be simply limited to chronological age. The fundamental purpose of the design...
17. November 2015
Introduction: According to the European Pharmacopoeia oromucosal films comprise mucoadhesive buccal films and orodispersible films. Both oral dosage forms receive considerable interest in the recent years as commercially available pharmaceutical products and as small scale personalized extemporaneous preparations. Areas covered: In this review technological issues such as viscosity of the casting liquid, mechanical properties of the film, upscaling and the stability of the casting solution and...