27. May 2018
A systematic assessment of key material attributes of active pharmaceutical ingredients (APIs) using minimal material approach is illustrated at the particulate level and bulk level. At a bulk level, flowability improvement of an API through crystal habit manipulation is exemplified. The impact of crystal structures and particulate properties (crystal habit and crystal size) on their mechanical behaviour were addressed by measuring powder tabletability. Bulk powder flow and tabletability were...
17. November 2016
Abstract In this work, the supercritical assisted injection in a liquid antisolvent (SAILA) has been proposed as a new technique to produce composite microparticles for drug controlled release. Coprecipitation has been attempted for different non-steroidal anti-inflammatory drugs (Diclofenac, DF, Piroxicam, PX, and Indomethacin, ID) using poly-lactic-co-glycolic (PLGA) as the polymer matrix; acetone has been used as the liquid solvent and water as the liquid antisolvent. Coprecipitation was...
14. July 2016
As a novel drug delivery approach, piroxicam an anti rheumatoid drug is loaded in microspheres prepared by chitosan as a polymer and coated with eudragit S-100 to prepare colon speci c microspheres which increases the bioavailability of the drug to the targeted area and in a controlled manner and reduces GI related side effects. In the present study chitosan microspheres were prepared using emulsion crosslinking technique, glutaraldehyde as a crosslinker and microencapsulation using phase...
25. May 2016
Abstract: The main aim of the present work was to develop colon specific piroxicam loaded alginate microspheres intended for the treatment of rheumatoid arthritis. A multiparticulate system with a combined property of pH sensitive and biodegradability was developed. Piroxicam microspheres were prepared by using ionotropic gelation technique and coated by using coacervation phase separation method using different ratios of eudragit S100 which is a pH sensitive polymer. Both coated and uncoated...
19. September 2015
Lipid-based formulations can be effective drug delivery systems for poorly water-soluble chemical entities, provided they are designed with careful selection of the excipients, based on their role in the delivery system and in relation to drug properties. The primary factor leading to increased bioavailability is the administration of the drug in a pre-dissolved state thereby avoiding the dissolution limiting step. More
19. September 2015
Hydrate formation of pharmaceutical compounds can affect critical drug properties such as solubility and dissolution. There is early on in development a need for a deeper understanding of how excipients influence mechanistically hydrate formation. More