03. October 2017
We report the first multicomponent crystal of desloratadine, an important anti-histamine drug, with a pharmaceutically acceptable coformer of benzoic acid. The single crystal structure analysis revealed that this novel multicomponent crystal is categorized as salt due to the proton transfer from benzoic acid to the desloratadine molecule.
01. October 2016
Abstract Flashing at tablet edges, an inevitable phenomenon when tableting a plastically deforming material under a high pressure, can introduce significant errors to tablet density and porosity determinations due to overestimated tablet thickness when tablet were measured out-of-die. Errors in tablet density determination also lead to errors in true density obtained by the Sun method, which is suitable for water-containing solids. Errors in true density and tablet porosity propagate to...
02. May 2016
In this study, we first developed a modernized indentation technique for measuring tablet hardness. This technique is featured by rapid digital image capture, using a calibrated light microscope, and precise area-determination. We then systematically studied effects of key experimental parameters, including indentation force, speed, and holding time, on measured hardness of a very soft material, hydroxypropyl cellulose, and a very hard material, dibasic calcium phosphate, to cover a wide range...