20. December 2017

The formulation and manufacturing of parenteral biotherapeutic products occur at the interface of science and regulatory concerns.

17. April 2016

Males and females respond differently to drugs: indeed, sex plays a crucial role in determining drug pharmacokinetics and pharmacodynamics. Excipients have also been shown to enhance the biovailability of drugs differently in men and women. The aim of this work was to investigate whether rodents are a good model in which to study sex-specific effects of polyethylene glycol 400 (PEG 400) on the bioavailability of ranitidine. Ranitidine (50 mg/Kg) was dissolved in water with different amounts of...