16. August 2018

Vaginal drug delivery is a promising route for the treatment and prevention of local and systemic diseases such as genital herpes or AIDS. Suitable excipients must be selected to optimize the residence time of formulations in vaginal mucosa and could be included in the formulation. Many polymers are excellent choices for the development of vaginal drug delivery systems due to their properties of mucoadhesion, biocompatibility and biodegradability. These polymers swell in the aqueous medium of...

13. August 2018

3D printing is an additive manufacturing technique capable of producing various 3D drug products, medical devices, tissues and organs from digital designs. The first FDA approved 3D drug product, Spritam®, has encouraged and attracted many researchers in this field with research undergoing to develop various customized dosage forms. This review aims to introduce 3D printing, its history, advantages, challenges and various techniques used in fabrication of drug products. This review also...

05. April 2018

Fused deposition modeling 3D printing (3DP) has a potential to change how we envision manufacturing in the pharmaceutical industry. A more common utilization for FDM is to build upon existing hot melt extrusion technology where the drug is dispersed in the polymer matrix. However, reliable manufacturing of drug-containing FDM filaments remains a challenge along with the limitation of active ingredients which can sustain the processing risks involved in the HME process. To circumvent this...

08. March 2018

Despite the enormous potential of nanomedicine, the search for materials from renewable resources that balance bio-medical requirements and engineering aspects is still challenging. This study proposes an easy method to make nanoparticles composed of oxidized starch and chitosan, both isolated from natural biopolymers. The careful adjustment of C/N ratio, polymer concentration and molecular weight allowed for tuning of particle characteristics.

26. December 2017

Micro sponge is a novel approach for targeting the drug to the colon for the management of colon ailments such as inflammatory bowel disease. Prednisolone loaded microsponges (PLMs) were prepared and coated with Eudragit S 100 (ES) and evaluated for colon specific drug delivery.

18. December 2017

Spray drying is a well-established scale-up technique for the production of cocrystals. However, to the best of our knowledge, the effect of introducing a third component into the feed solution during the spray drying process has never been investigated.

13. November 2017

Amorphous solid dispersions (SDs) are considered as one of the most effective strategies for the formulation of poorly water-soluble compounds. The active compound is dispersed in an inert carrier composed of a polymer and active excipients. Since the drug is amorphous, there is typically an increase in apparent solubility as well as dissolution rate. Various methods are employed for manufacturing of SDs, nevertheless, hot-melt extrusion (HME) has become one of the most common process techniques

10. November 2017

Mucoadhesive formulations are well known for the delivery of drugs via the mucosal membrane of oral (sub- lingual, buccal and gingival), rectum, nose, eyes, and vagi- na. Among the various drug delivery approaches, the buc- cal mucosa delivery system o ers several bene ts like easy accessibility, patient compliance, a relatively large surface area of absorption for drug molecules, reduced gastric ir- ritation and simple delivery devices.

27. October 2017

Polar, hydrophilic natural and synthetic polymers physically or chemically cross-linked into 3D-network and bonding a large amount of water (up to 100 g/g or higher), but insoluble in water are known as hydrogels (HG, water containing gels). The insolubility of HG in water is of importance for preservation of the system integrity.

06. July 2017

Utilizing spray-freeze-drying, solid dispersions of Azithromycin-PVA were prepared. The samples were characterized by the dissolution tests, FT-IR, DSC, PXRD and SEM. The dissolution and solubility of SFD-SD samples were significantly increased. The prepared samples can be used for the drug nano-suspensions or inhaled aerosols.