12. April 2018
The long-term stability of pharmaceutical formulations of poorly-soluble drugs in polymers determines their bioavailability and therapeutic applicability. However, these formulations do not only often tend to crystallize during storage, but also tend to undergo unwanted amorphous-amorphous phase separations (APS). Whereas the crystallization behavior of APIs in polymers has been measured and modeled during the last years, the APS phenomenon is still poorly understood. In this study, the...
05. March 2018
In spite of significant recent interest in polymeric films containing poorly water-soluble drugs, dissolution mechanism of thicker films has not been investigated. Consequently, release mechanisms of poorly water-soluble drugs from thicker hydroxypropyl methylcellulose (HPMC) films are investigated, including assessing thickness above which they exhibit zero-order drug release.
23. November 2017
The solubility behavior of drugs remains one of the most challenging aspects in formulation development. Solid dispersions (SD) and inclusion complexes (IC) are two of the most promising strategies to improve the oral bioavailability of poorly water-soluble drugs. Cyclodextrins (CDs) are cyclic carbohydrates of natural origin with a hydrophobic cavity and hydrophilic exterior.
03. July 2017
A modified coaxial electrospinning for creating hypromellose-based composite fibers.
Quantitative analyses of Taylor cone and straight fluid jet during electrospinning.
Amorphous hydrophilic nanocomposites consisting of multiple components.
Improved performances about the fast dissolution of poorly water-soluble drug.