25. June 2018
The blending of powders is a critical step in pharmaceutical drug product manufacturing as it ensures that each dosage unit will contain the same intended fraction of active pharmaceutical ingredient (API). Under-blending thus poses a significant risk to patients where overdose or underdose can occur. Similarly, over-blending can lead to manufacturing issues such as reduced tablet tensile strengths as any included lubricants are dispersed further and further with additional blending. For these...
19. June 2017
In this study, the origins of granule content non-uniformity in the high-shear wet granulation of a model two-component pharmaceutical blend were investigated. Using acetaminophen as the active pharmaceutical ingredient (API) and microcrystalline cellulose as the excipient, the distribution of the API across the granule size classes was measured for a range of conditions that differed in the duration of the initial dry mixing